The Lymphocyte MAP™
Comprehensive Lymphocyte Immunophenotyping
“Cyrex Immunophenotyping can change the way we evaluate our patients and help them achieve their immune harmony”
Aristo Vojdani, PhD
The Lymphocyte MAP™, is an innovative new test which establishes a new standard in screening the immune system. It measures the integrity of the immune system at the cellular level to help identify a patient’s immune status and immunotype(s), based on 28 key biomarkers and determinants.
Part of a regular check up
Performed by some labs for the purpose of detecting certain immune deficiencies including AIDS
Exclusive immunophenotyping to help identify immune deficiency, immune over-activity, infections, inflammation, autoimmunities, allergies, asthma, hypersensitivities, and cancers
Lymphocytes and their subpopulations are the key elements of the immune system. In adults, they account for about 20-49% of the total number of white blood cells. It would be vitally important to measure decrease or increase in the percentage and number of these important lymphocytes. It is the numbers, ratios, percentages and activity level of these lymphocytes, and their subpopulations which are responsible for protection against various environmental factors, including viruses.
When healthy, these NRPAs are in a precise and pre-determined relationship to one-another. It is the disruption of these finely balanced relationships which can compromise the immune function.
These are NOT measured by a CBC test, which is just part of a yearly checkup. There is a significant difference between lymphocyte immunophenotyping and the complete blood count (CBC), which is used for checking the overall health of a patient.
A CBC could be absolutely normal, but the patient could actually be suffering from immune dysfunction, which includes immune deficiencies, hidden inflammation, autoimmunities, hypersensitivities and allergies induced by environmental triggers. These immune disorders can be detected by the advanced immunophenotyping of lymphocytes done by Cyrex Labs.
These industry-changing features result in a more accurate picture of T-helper cell status than currently available on the market.
The Lymphocyte MAP can:
The Lymphocyte MAP opens a new world for the immune system analysis and identifies important correlations with disease conditions.
Cyrex Immunotype classifications are based solely on, and refer solely to, absolute lymphocyte counts and their subsets. Immunotypes are identifiable patterns that show the immune system is responding to circumstances or environmental factors. While cell counts and immunotypes may provide valuable insights, they are not indicative of any specific condition or disease and should not be used alone to interpret the results. The Lymphocyte MAP™ provides two important categories of information: (1) each parameter/determinant provides important information on its own, and (2) the relationship between parameters provides another set of invaluable information categorized in multiple immunotypes (immunophenotype patterns).
Immunotype 1. Immune balance or harmony at the time of testing, due to one of the following: Total Cell Counts are all within the reference range; some determinants (percentages or ratios) may be out-of-range.
Immunotype 2. T cell Dominance at the time of testing, due to one of the following: high T cell with normal or low B cell, or normal T cell with low B cell results.
Immunotype 3. B cell Dominance at the time of testing, due to one of the following: high B cell with normal or low T cell, or normal B cell with low T cell results.
Immunotype 4. Immune Hyperactivity/CD4 Dominance at the time of testing, due to one of the following: high CD4 with normal or low CD8, or normal CD4 with low CD8 results.
Immunotype 5. Immune Deficiency/CD8 Dominance at the time of testing, due to one of the following: high CD8 with normal or low CD4, or normal CD8 with low CD4 results.
Immunotype 6. Th1 Dominance at the time of testing, due to one of the following: high Th1 with normal or low Th2, or normal Th1 with low Th2 results.
Immunotype 7. Th2 Dominance at the time of testing, due to one of the following: high Th2 with normal or low Th1, or normal Th2 with low Th1 results.
Immunotype 8. Regulatory T cell Imbalance at the time of testing, due to one of the following: high or low regulatory T cell results.
Immunotype 9. Th17 Dominance at the time of testing, due to one of the following: high Th17 with normal or low Treg, or normal Th17 with low Treg results.
Immunotype 10. Th1+Th17 Dominance at the time of testing, due to one of the following: high Th1+Th17 with normal or low Treg.
Immunotype 11. Th2+Th17 Dominance at the time of testing, due to one of the following: high Th2+Th17 with normal or low Treg.
Immunotype 12. NK Cell Imbalance at the time of testing, due to one of the following: high or low NK or Cytotoxic NK cell results.
Immunotype 13. NKT Cell Imbalance at the time of testing, due to one of the following: high or low NKT cell results.
Low numbers of lymphocytes and their subsets may result in one or more absolute counts being out of range, while other absolute counts might even be over the high limits of the given range, but in certain cases the results would not fit within the Cyrex-defined criteria for Immunotypes 1-13. Under such circumstances the results would be labeled as No Immunotypes Apply at time of testing.
The following are examples of certain immunotypes:
More in-depth details on this advanced panel can be found in:
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Since opening in 2011, Cyrex has been the functional medicine practitioner’s go-to lab for assessing environmentally-induced autoimmunity.